In this study, we explore the application of simple spread trading strategies using Bitcoin ETFs and cryptocurrency infrastructure ETFs—two highly correlated asset classes due to the broader influence of cryptocurrency market movements. Given their strong relationship, this setup provides a compelling case for implementing pair trading strategies based on mean reversion principles. Building on our previous work, How to Build Mean Reversion Strategies in Currencies, we adapt and extend these models to the cryptocurrency ETF space, demonstrating their broader applicability beyond traditional currency markets. Specifically, we test two sub-methods of mean reversion: linear and exponential. Our goal is to offer a clear and practical example of how traders can leverage these techniques across different asset classes.